The Cortisol Awakening Response (CAR) test is a non-invasive saliva test that serves as a reliable marker of stress response and a critical tool for revealing adrenal imbalances. Lifestyle, physical and psychological stresses put constant demands on the adrenal glands. If they become depleted adrenal fatigue or insufficiency may be experienced.

The Cortisol Awakening Response (CAR) test is a unique assessment measuring the predictable rise and fall in cortisol within the first hour of awakening. The test is essential in evaluating the overall function of the HPA axis. In this particular test, we measure cortisol immediately on rising, 30 minutes post waking, 60 minutes post waking, 12:00 (noon), 4:00 pm and 8:00 pm.

The CAR test allows your physician to determine how healthy your HPA axis is which is a good tool for overall health status.

The CAR test is an appropriate tool in practice for most of your patients as it provides an easy assessment of their ability to deal with stressors and is also reflective of how well they have dealt with stressors in the past.

Common Conditions:

• Anxiety

• Headaches

• Brain Fog

• Energy levels

• Fatigue

• Salt cravings

• Mild depression

• Lack of stamina

• Sexual dysfunction

• Sleep disorders

• Thyroid dysfunction

• Blood pressure issues

• Impaired immune system

The Extensive Neurotransmitter Profile is a urine test, assessing levels of 6 neurotransmitters: serotonin + GABA + dopamine + noradrenaline + adrenaline + glutamate. These neurotransmitters are the most researched in relation to their effects on mood disorders, hormones, sleep, glucose/insulin balance, pain perception, appetite and cognitive function.

Low or high levels of neurotransmitters are observed in various mental health disorders, such as depression, attention-deficit hyperactivity disorder (ADHD), Parkinson’s disease and panic attacks.

The report format includes a correlation analysis section, written by the clinical department, which relates the patients’ symptoms with their corresponding lab results, as an aide to the practitioner.

Serotonin

Serotonin (5-hydroxytryptamine) is an inhibitory neurotransmitter synthesised in serotonergic neurons in the central nervous system (CNS) and enterochromaffin cells of the gastrointestinal tract.

Dopamine

Dopamine is an excitatory and inhibitory neurotransmitter synthesized in many areas of the brain.

Noradrenaline and Adrenaline

Noradrenaline (norepinephrine) and adrenaline (epinephrine) are excitatory neurotransmitters as well as hormones.

GABA

GABA (gamma-aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the brain.

Glutamate

Glutamate is a major mediator of excitatory signals in the brain and is involved in most aspects of normal brain function including cognition, memory and learning.

Thyroid abnormalities are one of the most common endocrine disorders affecting millions worldwide. Thyroid hormones are well known for their role in basal metabolic rate, development and growth. Hypothyroidism affects approximately 4-5% of the population whilst estimates for hyperthyroidism are 0.4-2%.

Thyroid abnormalities have become a quiet epidemic worldwide. The thyroid has just one job, however, it is one of the most important jobs for the body to function properly. The thyroid makes hormones that regulate the energy level, growth, and reproduction of every cell of your body. That means your brain, heart, lungs, liver, skin, tissues and other body parts depend on your thyroid to stay “powered up” and active, and to remain healthy by generating new cells to replace old ones.

The Thyroid Profile Extensive is a hormone test designed to provide a comprehensive analysis of thyroid hormone metabolism. It includes central thyroid gland regulation and activity, thyroid production and secretion, peripheral thyroid conversion, and thyroid autoimmunity. The Extensive thyroid panel allows the practitioner to pinpoint common imbalances that may be causing chronic illnesses. The comprehensive panel measures levels of TSH, free T4, free T3, reverse T3, anti-TG antibodies, and anti-TPO antibodies to assess central and peripheral thyroid function, as well as thyroid auto-immunity.

Iodine Deficiency is the most common worldwide cause of thyroid disorders. A low iodine diet can cause hypothyroidism, and an enlarged thyroid gland (goitre) and can affect fertility, pregnancy and neuro-developmental disorders in newborns.

Research has indicated that severe iodine deficiency has more than quadrupled in Australia over the last 20 years; increasing from 2.6% to 11.7%. Even more disconcerting is the observation that nearly half of the pregnant women in these areas also have this mineral deficiency.

Random Iodine Test

The standard procedure used to detect iodine deficiencies. It measures iodine levels in a random urinary specimen. The disadvantage of this is it is not a sensitive test for detecting mild or moderate iodine deficiencies.

Common Conditions:

• Hypothyroidism

• Decreased fertility

• Fibrocystic breast disease

• Estrogen imbalance

• Fatigue

• Depression

• Weight gain

The MethylDetox Profile gives more actionable information than MTHFR testing alone, giving you a complete picture of your body’s methylation and detoxification. The MethylDetox profile includes Smart commentaries, detailing recommended nutrients based on your genetics.

Standard MTHFR genotyping only evaluates folic acid metabolism. Scientific research reveals that a variety of genes are involved in maintaining methionine/homocysteine balance. Genetic variations (SNPs) in these important genes influence your methylation potential. Individual methylation is monitored using homocysteine levels. Important SNPs are included to evaluate your ability to methylate neurotransmitters, DNA and toxins.

Individual analytes of this profile may be ordered. However, please note that pricing will vary depending on the customised selected analyte requested.

Common Conditions:

• Anxiety

• Insomnia

• Fatigue

• Depression

• Autism

The organic acids test is a simple urine test that looks at biomarkers from various metabolic pathways. These biomarkers give an overview of several major systems in the body and an analysis of nutritional deficiencies in the body. The organic acid test is a nutritional test that provides insights into the body’s cellular metabolic processes. Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, a toxic build-up or a drug effect.

The Organic Acids metabolic test is the preferred test used in clinical practice as many functional medicine practitioners believe the metabolic panel provides remarkable data about a patient from one simple urine collection kit. This test assesses a wide range of cellular and physiological processes including intestinal dysbiosis, energy production, nutrient cofactor requirements and neurotransmitter metabolism. By evaluating organic acid levels and pinpointing the metabolic dysfunctions occurring at the cellular level, a comprehensive, customised treatment strategy can be tailor-made for each individual patient.

This test is the single most comprehensive test in evaluating:

• Citric acid cycle abnormalities

• B-group vitamin utilisation

• Neurotransmitter abnormalities

• CoQ 10 sufficiency

• Amino acid insufficiencies

• GUT Dysbiosis

• Yeast infestation

• Nutritional deficiencies

• Fatty acid metabolism

Common Conditions:

• Fatigue

• Mood changes

• Blood sugar dysregulation

• Weight gain

• Nausea

• Multiple chemical sensitivity

• Bloating, gas and distention

• Joint pain

• Acid reflux

• Autoimmune disorders

• Dermatitis

The CDSA Level 3+ is the second most comprehensive stool assessment which is the extended test of the CDSA level 3 panel with the additional advanced biomarkers that evaluate digestion, absorption, pancreatic function, and inflammation such as Transglutaminase IgA, Eosinophil Protein X, Calprotectin, M2 Pyruvate Kinase (M2-PK) and H.Pylori. The CDSA level 3+ offers a comprehensive look at the overall health of the gastrointestinal (GI) tract. It helps identify inflammatory conditions such as IBD (Inflammatory Bowel Disease), food allergies and post-infectious Irritable Bowel Syndrome (IBS). This profile also includes sensitivity testing meaning that when colonising bacteria or mycoses/yeasts are detected, they are tested against a panel of natural anti-microbial and prescription anti-fungal agents to assist the practitioner in selecting what treatment will be most effective for the patient. It is recommended to add a DNA Multiplex PCR (2002) test to any CDSA level if you suspect parasites.

In the last few decades, DNA analysis has transformed the field of microbiology and gut health testing. The Human Microbiome Project and research around the globe have characterized the GI microbiome. More than ever before, we are keenly aware of the health benefits and disease risks brought about by the microorganisms that inhabit the GI tract.

The Complete Microbiome Mapping Test was designed to assess a patient’s microbiome from a single stool sample, with particular attention to microbes that cause disease or that disrupt normal microbial balance and contribute to perturbations in the GI flora and contribute to illness.

The panel is a comprehensive collection of microbial targets as well as immune and digestive markers. It screens for pathogenic bacteria, commensal bacteria, opportunistic pathogens, fungi, viruses, and parasites.

Common Conditions:

• IBS/IBD

• Abdominal cramps or pain

• Leaky gut symptoms

• SIBO

• Allergies

• Weakness

• Diarrhoea

• Bloating

• Fatigue

This simple, non–invasive, gastrointestinal test detects bacterial overgrowth in the small intestine, often referred to as BOSI or SIBO. Small intestine bacterial overgrowth (SIBO) is a common gastrointestinal disorder that often underlies chronic gastrointestinal symptoms of maldigestion and malabsorption, including bloating, gas, diarrhea, irregularity, and abdominal pain

Bacterial concentrations in the small intestine are normally kept to a minimum. When excessive, the delicate mucosal lining is disrupted, including the microvilli that facilitate absorption. As a result, bacterial overgrowth of the small intestine (BOSI) can inhibit nutrient absorption and lead to the following serious health problems.

How you can assist once you have a test report for SIBO?

Once bacterial overgrowth has been detected, intervention strategies involving diet, digestive support, probiotics and antimicrobials can be used to treat the condition.

Successful eradication of BOSI has been shown to reduce bloating, gas, diarrhoea, and abdominal pain in patients more effectively than many other treatments for IBS.

Bacterial overgrowth may manifest silently, without overt clinical signs. Patients without clear symptoms of gastrointestinal distress may benefit from testing, especially those with a history of chronic constipation, hypochlorhydria (including use of acid-blocking drugs), or maldigestion.

Common Conditions:

• Irritable Bowel Syndrome (IBS)

• Unexplained abdominal symptoms

• Gas and bloating

• The inability to tolerate sweet or starchy foods, fibre, or friendly flora supplements

The aging male experiences a decrease in testosterone at a rate of 10% per decade from the age of 30. This reduction of testosterone and other androgens experienced as a consequence of the ageing process has been named andropause or androgen deficiency of the ageing male (ADAM).

The Male extensive profile is an expanded profile on the male hormone profile in the sense that it investigates additional endocrine markers such as Dihydrotestosterone (DHT) which is a natural but powerful metabolite of the human body and the main cause of hair loss in men and Androstenedione which is a steroid hormone that has weak, androgenic actions on the body itself. However, acts as a stepping stone in the manufacture of testosterone and oestrogen within the body.

As the body ages, it is evident that particular hormones decline or fluctuate causing a variety of health conditions. This unique profile will provide valuable information on an individual’s hormonal status. The Male hormone profile will provide insights into a wide range of disorders, from reduced libido and muscle mass to cardiovascular disease and other hormone related imbalanced symptoms.

Salivary hormone testing is particularly ideal for the prevention and treatment of hormone related symptoms and conditions, prescribing and monitoring Hormone Replacement Therapy (HRT) and natural hormone replacement therapy. Salivary Hormone testing is unique in that it helps identify the hormonal imbalances that may be causing chronic health problems. From just one simple non-invasive collection, results obtained from the test make it possible for practitioners to individualise treatment in order to establish optimal hormone balance.

Common Conditions:

• Poor memory

• Poor attention/focus

• Fatigue

• Anxiety and Depression

• Erectile dysfunction

• Muscle weakness

• Loss of libido

• Impaired immune system

• Prostate cancer

Hormones are crucial to a woman's reproductive health. The main hormones affecting the menstrual cycle and fertility are produced by glands in the brain and by the ovaries. Those hormones regulate menstruation, fertility and sex drive (libido) – any one of which can be adversely affected if the production of these hormones goes out of balance. As most women approach mid-life, hormonal changes gradually cause reproductive organs to shut down eventually leading to menopause.

Hormones are tremendously complex and during the pre-menopausal years, imbalanced hormones can pose challenges with mood stabilisation, conception and regulation of your menstrual cycle. The female hormone profile extensively expands on the basic female hormone profiles in that it investigates androstenedione. Androstenedione is a steroid hormone that has weak, androgenic actions on the body itself. However, acts as a stepping stone in the manufacture of testosterone and oestrogen within the body.

Hormone-related symptoms can occur from the age of when a menstrual cycle commences. Generally, hormonal issues are not a clear-cut case of one hormone level being abnormal, or even one hormone system. In fact, because of the role that hormones play as chemical messengers to wake up the genome in specific target tissues throughout the body, it makes sense that all hormone systems work in concert with each other to maintain a state of balance.

Salivary hormone measurements are the most accurate analyses of estrogens, progesterone, and testosterone in determining the need for hormone replacement therapy (HRT). Hormone levels may be normal, indicating that hormone replacement therapy (HRT) is not needed.

Common Conditions:

• Hot flushes

• Weight gain

• Night sweats

• Depression

• Irregular menstruation

• Mood changes

• Brain fog

• Vaginal dryness

• Bone loss

• Dry skin

• Fatigue

• Insomnia

• Disturbed sleep patterns

• Low libido

• Infertility

• Miscarriage

• PMS

• Symptoms of menopause

Heavy metal toxicity is a common issue in Australia and lots of people are widely affected by this health condition. Heavy metals, such as mercury, lead and aluminium, can accumulate in the body over time and can lead to a number of concerning symptoms and health conditions. Heavy metal toxicity is primarily caused by the levels of pollution and use of chemicals that we are exposed to on a day to day basis.

Analytes:

• Aluminium (Al)

• Arsenic (As)

• Beryllium (Be)

• Bismuth (Bi)

• Cadmium (Cd)

• Mercury (Hg)

• Nickel (Ni)

• Lead (Pb)

• Platinum (Pt)

• Antimony (Sb)

• Tin (Sn)

• Thallium (TI)

• Silver (Ag)

• Barium (Ba)

The urine toxic metal analysis test is a remarkable tool for the assessment of fourteen toxic metals in the sense that only a simple spot urine collection is needed. The spot urine assessment is useful for patients who are extremely busy and simply do not have the time to collect a 24 hour urine sample. However, if you are taking a chelating agent and wanting to assess the POST chelation of toxic metals, it is mandatory that a 24 hour urine sample is collected.

Common Conditions:

• Mental health disorders

• Foggy memory

• Impairment of vital organ systems

• Toxicity

• Allergies

• Immune dysfunction

• Thyroid dysfunction

• Cardiovascular disease

• Muscular skeletal conditions

• Metabolic syndrome

• Skin conditions

The Mauve Factor test (formerly known as Kryptopyrroles) is a urinary test that analyses the level of HPL, a neurotoxic substance found in high levels in schizophrenia, autism, ADHD, alcoholism, violent offenders and other mental health disorders. High levels of the Mauve Factor are associated with vitamin B6 and zinc deficiencies, and treatment with these nutrients results in symptom resolution, as well as lowered levels of the urinary mauve factor.

Pfeiffer, who was one of the initial investigators of Mauve, treated more than one thousand high-Mauve patients with vitamin B6 and zinc with very positive results. Symptom improvement with these supplements can be experienced in patients in as little as two days and Mauve levels have been observed to decrease by as much as 50% after one month of treatment. However, discontinuation of the supplement regime may result in deterioration of the patient in as little as 48 hours. Correlation studies have provided evidence of zinc and functional vitamin B6 deficiencies in high-mauve patients, supporting the use of these nutrients in the treatment of Mauve. Many of the symptoms observed in high-Mauve patients can be attributed to zinc, vitamin B6 and biotin deficiencies. Furthermore, many neurotransmitters such as serotonin, dopamine and GABA require vitamin B6 and/or zinc for their production.

Multiple compounding factors have fuelled opposition to the relevance of the Mauve Factor to mental health disorders. One area is the incorrect chemical identification of the Mauve Factor and the subsequent erroneous naming (kryptopyrrole) of this neurotoxic compound. Kryptopyrrole is the term that the Pfeiffer Centre has used in the past for the Mauve Factor and this term has been in use for more than 20 years. However, it has recently come to the attention of those involved in this area of research that the term ‘kryptopyrrole’ is scientifically inaccurate, and the Mauve Factor has been identified as hydroxyhemopyrrolin-2-one (HPL).

Common Conditions:

• Abdominal pain

• Impotence in males

• Acne

• Irregular periods

• Allergies

• Migraines

• Anxiety

• Morning nausea

• Attention (Deficit/Hyperactivity)

• Depression

Food sensitivities can cause a wide range of symptoms and disorders. The foods that cause these delayed reactions are often hard to diagnose because of the time between consumption and the physical reaction. The IgG food allergy test offers a useful tool for detecting the foods causing this response. The results are patient-specific and provide an easy, precise and effective starting point for dietary manipulation.

IgG (immunoglobulin G) testing is a useful guide for practitioners to structure an elimination diet for many chronic health conditions. The foods that cause these delayed reactions are often hard to diagnose because of the time between consumption and the physical reaction. Generally, an IgG reaction occurs hours to days after exposure to these food antigens.

The IgG food allergy test offers a useful tool for detecting the foods causing this response. The results are patient-specific and provide an easy, precise and effective starting point for dietary manipulation.

When doing an IgG test, it is recommended to eat a large variety of foods in the two weeks before testing. Include as many of the foods that are being tested in the specific allergy panel you have chosen. Be aware that if foods are not included in the diet during this time, false negative results may be obtained as recent exposure to these foods may be required for antibodies to be present in the blood.

It is recommended that IgG allergy testing is only performed for infants greater than 18 months of age.

Common Conditions:

• Asthma

• Headaches

• Eczema

• Fatigue

• Irritable Bowel

Intolerances/Sensitivities to foods + food additives + food chemicals + environmental chemicals + herbs/dietary supplements + moulds can cause a wide range of symptoms and disorders. The ALCAT® diagnostic system detects changes in the size and number of leucocytes (i.e. immune cells) in response to exposure to the offending foods, chemicals, additives, herbs and moulds.

The ALCAT® diagnostic system is a useful test that can be used to screen for intolerance and sensitivities to:

• Foods

• Food Additives

• Food Chemicals

• Environmental Chemicals

• Herbs/Dietary Supplements

• Antibiotics and Anti-inflammatories

• Moulds

This diagnostic system detects changes in the size and number of leucocytes (i.e. immune cells) in response to exposure to these analytes.

A significant advantage of this system is that it uses whole blood which contains all of the immune factors, cells and serum proteins that might be involved in an adverse reaction to foods, chemicals and moulds. Regardless of the pathways that may underlie an adverse reaction to an analyte, i.e. immune or non-immune, the final common pathway may involve the release of chemical mediators. These substances such as histamine and cytokines will alter the activity of the white blood cells which is detectable using the ALCAT® technique. In addition, the ALCAT® test will theoretically detect changes in the innate immune system (phagocytic white blood cells) and any cytotoxic effects of a tested analyte.

The Pathway FIT profile analyzes over 80 genetic markers known to impact metabolism, exercise and energy use within the human body.

Pathway FIT examines specific genetic markers to give you personal insight into how your body processes sugars, fats, vitamins and nutrients. The final laboratory report includes a detailed analysis of how your body responds to exercise based on your genetics. By providing an individualised road map of strategies and recommendations, our testing guides you towards optimal health.

The PATHWAYFIT will assist you with information about:

• Diet

• Eating Behavior Traits

• Food Reactions

• Nutritional Needs

• Exercise

• Body and Weight

• Metabolic

• Health Factors

From this report, you can then:

• Promote Behavioural Changes with Your Personalized Genetic Nutrition and Fitness Profile

• Gain Insight into Your Health and Wellness

• Make Proactive Decisions Regarding Diet, Exercise & Lifestyle